Contrave UK

Contrave UK is a prescription weight-management medication that combines two active substances:

• Naltrexone hydrochloride (an opioid receptor antagonist)

• Bupropion hydrochloride (a norepinephrine–dopamine reuptake inhibitor, also used as an antidepressant and for smoking cessation). semaglutide-weight-loss

Contrave Overview

1. Indication

• Used as an adjunct to reduced-calorie diet and increased physical activity for chronic weight management in adults with:

  • BMI ≥30 (obesity), or

  • BMI ≥27 (overweight) with at least one weight-related comorbidity (e.g., type 2 diabetes, hypertension, dyslipidaemia).crizotinib-spc

2. Mechanism of action

• Bupropion: influences brain pathways regulating appetite and reward (dopamine and norepinephrine).

• Naltrexone: blocks opioid receptors, thought to reduce cravings and help control eating behaviour.

• Together, they act on the hypothalamus (hunger regulation) and mesolimbic dopamine circuit (reward pathway).oxycodone-10mg

3. Dosage (adults)

• Oral extended-release tablets (naltrexone 8 mg / bupropion 90 mg).

• Titrated up over 4 weeks to a maintenance dose of 2 tablets twice daily (32 mg naltrexone + 360 mg bupropion total daily).

• Tablets should be swallowed whole, not crushed or chewed.oxycodone-tablets

4. Common side effects

• Nausea, constipation, vomiting

• Headache, dizziness, insomnia

• Dry mouth, diarrhoea

• Increased blood pressure and heart rate

5. Warnings & precautions

• Contraindicated in patients with:

  • Uncontrolled hypertension

  • Seizure disorders

  • Chronic opioid use or acute opioid withdrawal

  • Anorexia nervosa or bulimia

  • During abrupt discontinuation of alcohol, benzodiazepines, barbiturates, or antiepileptics

• Risk of neuropsychiatric effects (e.g., suicidal thoughts, depression) — monitor carefully

• Can lower seizure threshold, especially at higher doses or with alcohol use. metronidazole-tablet

6. Legal status

• Prescription-only medicine in the US, EU, and many other regions.

• Marketed under different names (e.g., Mysimba® in Europe).

✅ In short: Contrave (naltrexone/bupropion) is a prescription drug for weight management that works on both appetite control and cravings, but it must be used with caution due to psychiatric risks, seizure risk, and cardiovascular effects.tramadol-hydrochloride-100mg