sibutramine uk

Sibutramine UK is a weight-loss drug that was once widely prescribed but is now banned in most countries due to serious safety concerns.phentermine-uk

Sibutramine – Overview

1. What it is

• A centrally acting appetite suppressant.

• Belongs to the class of serotonin–norepinephrine reuptake inhibitors (SNRIs), though it was not used as an antidepressant.

• Marketed under trade names such as Reductil, Meridia, and others.

2. Medical use (before withdrawal)

• Approved for treatment of obesity, in combination with diet and exercise.

• Indicated for adults with:

  • BMI ≥30 kg/m², or

  • BMI ≥27 kg/m² with risk factors (e.g., type 2 diabetes, dyslipidaemia, hypertension).

3. Mechanism of action

• Inhibits reuptake of serotonin, norepinephrine, and dopamine in the brain.

• Increases satiety (feeling of fullness) and slightly raises metabolic rate.oxycontin-uk

4. Adverse effects

Common side effects:

• Dry mouth, insomnia, constipation

• Increased heart rate and blood pressure

• Sweating, headache, anxiety

Serious risks (led to withdrawal):

• Increased risk of heart attack and stroke in patients with cardiovascular disease

• Arrhythmias, hypertension

• Potential for psychiatric effects (depression, mood changes)

5. Withdrawal from market

• Large clinical trial (SCOUT study) showed significantly higher rates of cardiovascular events in sibutramine users vs placebo.

• Result:

  • 2009–2010: Withdrawn in EU, US, UK, Australia, and many other countries.

  • Today: not legally available as a medicine, but still found in some illegal or counterfeit “slimming pills” sold online.mdma-uk-ecstasy

6. Legal status

• USA: Withdrawn (FDA, 2010).

• Europe: Suspended by EMA in 2010.

• Most countries: Banned due to safety concerns.

✅ In short: Sibutramine was once prescribed for weight loss but is now globally banned because of its strong link to heart attack, stroke, and sudden death, especially in patients with cardiovascular risk.quaalude